descurainia sophia side effects

Ethical ApprovalThe protocol of this trial was approved by Office of Research Affairs, Deputy of Research and Technology, Shahid Beheshti University of Medical Sciences (Reference Number: 150). So we decided to use the items of the PAC-SYM questionnaire to evaluate patients’ constipation-related symptoms. So we hypothesized that Descurainia sophia is useful for functional constipation. No statistically significant difference was found between the efficacy of both interventions in the treatment of constipation at the end of the third and eighth weeks of intervention. Descurainia sophia seed, also known as flixweed, is a member of Brassicaceae family. Khodarahmi et al. No statistically significant difference was found between the efficacy of both interventions in the treatment of constipation at the end of the third and eighth weeks of intervention. It reproduces by seeds.It is a dominant weed in dark brown prairie and black prairie soils of southern Alberta. With the exception a few patients, reported mild adverse events mainly included headache, nausea, and increased bloating, which were very mild and did not lead to discontinuation from the study; the other patients tolerated the drug easily. I have read and accept the terms and conditions, View permissions information for this article. Spanish: ajenjo loco; ajenjo serifio; hieba de la sabiduría; hierba de los cirujanos; Sofia. The mechanism of Descurainia sophia has not yet been exactly known. Either patients or investigator had a moderate satisfaction with the treatment (66 and 69, respectively, in visual analogue scale). One patient reported an increase in severity of her constipation and withdrew from the study. Canadian Journal of Plant Science. The present study is the first to have been undertaken to investigate the potential efficacy of Descurainia sophia L. in the management of adult patients with chronic functional constipation by standard assessments. It belongs to the Brassicaceae family. Journal of Evidence-Based Complementary & Alte... Categorization of Functional Constipation in Traditional Persian Medicine: A Descriptive Study. Members of _ can log in with their society credentials below, Journal of Evidence-Based Integrative Medicine, This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (. Some adverse effects of Descurainia sophia (L.) Seeds of Descurainia sophia (L.) have been reported to contain high concentrations of some glucosinolates (a group of sulphur Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Problema out in the market na, I don't know why.. sayang affordable pa nman unlike sa ibang pills in the market. significant adverse effects such as bone-marrow suppression, fatigue, gastrointestinal complications, loss of appetite, body-weight loss, etc., and often in significant negative effects on the healthrelated - quality of life. The results reported herein with Descurainia sophia are difficult to compare with other agents because of differences in study design. Available: https://www.fs.fed.us/database/feis/plants/forb/dessop/all.html [2020, June 2]. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Patients provided written informed consent before trial entry. Synonyms: Arabis sophia, Sisymbrium sophia Common names: tansy mustard, flixweed Descurainia sophia (flixweed) is an annual or biennial (family Brassicaceae) found throughout California along roadsides, in agricultural fields, disturbed desert areas, scrub, grasslands and woodlands. In addition, such side effects may limit treatment programs and hence may affect the prognosis for patients. After treatment, 94.3% of the patients did not use any laxatives and 5.8% of them used 1 or 2 laxatives/week (data not provided). evaluated the cytotoxic effects of volatile oil from D. sophia seeds on the MCF-7 and HeLa cell lines with an IC 50 of 70 μg/mL and 180 μg/mL, respectively . With the exception a few patients, reported mild adverse events mainly included headache, nausea, and increased bloating, which were very mild and did not lead to discontinuation from the study; the other patients tolerated the drug easily. The mean types of their stools, according to the Bristol chart, before and after intervention, are displayed in Table 3 (1.83 and 3.34, respectively, P < .001 by Wilcoxon signed-rank test). The enrolled patients included patients aged 18 to 75 years with chronic functional constipation defined based on Rome III criteria for functional constipation.19 Patients should have had 2 or more of the following symptoms during 25% or more of their bowel movements for at least the past 6 months: less than 3 spontaneous complete bowel movements per week (CSBMs/week), hard/lumpy stools, straining during defecation, and sensation of incomplete evacuation. 1. It not only shows more rapid response than salicylic acid, but also has fewer side effects. glabrata N.Busch Descurainia sophia var. They all were allowed their own laxatives during the study if a patient, despite increasing medication as directed by the researcher, had not had a satisfied bowel movement for 3 consecutive days. Italy: erba Sofia. All authors edited and approved the final version of the article. Summary of Invasiveness Top of page. The clinical studies did not indicate any significant adverse effects of Descurainia sophia, demonstrating that it is a safe and effective herbal medicine. In the present study, we evaluated the 28‐day oral toxicity and the genotoxicity of BP10A. Descurainia sophia is one of the medicinal herbs which he emphasized on the usefulness and therapeutic effects. Patients provided written informed consent before trial entry. All data were first tested by 1-sample Kolmogorov-Smirnov test. It tolerates dry soil, but is not salt tolerant" (Fire Effects Information System). FundingThe authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors thank the financial support (Grant No. It belongs to the Brassicaceae family. Complementary and alternative medicine has introduced many remedies to ameliorate constipation symptoms.8 Similarly, Iranian traditional medicine introduces some therapeutic methods for treating constipation such as lifestyle changes especially in dietary intake and pharmacological intervention.9–11. Create a link to share a read only version of this article with your colleagues and friends. This product could help you, Accessing resources off campus can be a challenge. They mainly were reported by the patients and rarely were discovered by researcher. Descurainia sophia is a member of the family Brassicaceae. Fifty-four (4%) patients had ≥3 complete spontaneous bowel movements per week. Table 1. 3, May-Jun 2016 267 inflammatory as well as antipyretic effects have been experimentally assessed. In traditional Chinese medicine it is commonly used to manage cough and asthma.12,13 This plant in the largest traditional pharmacopeia of Iranian (Persian) traditional medicine,14Makhzan-al-adviyah (The Storehouse of Medicaments), is known as Khobbah,15 and among folk medicine practitioners it is famous as Khaksheer. The mean change from baseline in overall scores and their subscales are also illustrated in Table 2. Please read and accept the terms and conditions and check the box to generate a sharing link. England and Wales: piblys. Descurainia sophia seed, also known as flixweed, is a member of Brassicaceae family. In addition, compared with before treatment, patients reported using significantly fewer laxatives per week (Table 3). Descurainia sophia L. known commonly as flixweed acts as first-line medical treatment for constipation in Iranian traditional medicine. For evaluating the constipation-related symptoms, we did not have any Persian-version validated questionnaire of any kind up to the time of study initiation. Forty-two patients enrolled in the study with confirmed functional constipation from the Department of Gastroenterology in Shariati Hospital and Shariatpanahi Iranian Traditional Medicine Clinic. At the screening, before intervention, PAC-SYM items scores (average of 12 items) were predominantly (in 91.5% of patients) moderate to severe (overall score >1, ≤3; Table 1). Diuretic herbs are those herbs which increase the flow of urine. All eligible patients passed 1 week of washout period of their laxatives. Portuguese: erva-Sofia. Table 1. If the dose of drug was not sufficient to generate complete bowel movement, they were recommended to increase the Descurainia sophia dose every 3 days to reach a satisfactory level. Secondary constipation to cases such as surgery, bowel pathology, or medication use was the main exclusion criteria of the trial. If the dose of drug was not sufficient to generate complete bowel movement, they were recommended to increase the Descurainia sophia dose every 3 days to reach a satisfactory level. Its large effect was not limited to stool symptoms, and Descurainia sophia had a large effect on rectal symptoms and a moderate effect on abdominal symptoms (Table 2). Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors. 133) granted by the School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fifty-four (4%) patients had ≥3 complete spontaneous bowel movements per week. All statistical tests were performed using SPSS version 21.0, and a value of P < .05 was taken to indicate statistical significance. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? After treatment, 94.3% of the patients did not use any laxatives and 5.8% of them used 1 or 2 laxatives/week (data not provided). The Rome III criteria for functional constipation were the basis for diagnosis. In modern pharmacology, Descurainia sophia has anti-inflammatory, analgesic, antipyretic, and anticancer activity.13 These pharmacologic properties get more interesting when it is noticed that Descurainia sophia is a highly safe herbal medicine.12,16 Despite its broad administration in traditional and folk medicines, there are few clinical trials evaluating its pharmacological activities.13,17 A study conducted in Iran showed that a combination of Descurainia sophia and prune (Prunus domestica L.) could prevent constipation in adult Hajj pilgrims.18 A similar study from another part of our country showed that Descurainia sophia can be used as a cheap and safe alternative to conventional polyethylene glycol in the management of functional constipation in children.17 The aim of this study was to assess the efficacy and safety of Descurainia sophia for treating functional constipation by standard assessments. Zajímavosti ze světa rostlin. The overall and subscale score changes are illustrated in Table 2. Descurainia sophia is safe and effective in the treatment of chronic functional constipation. This plant is native to Asia, Africa, and Europe and is generally used as food additive and a medicinal herb in Iranian, Chinese, and Indian traditional medicines. effects of Descurainia sophia on small cell carcinoma of the lung [28,29], colon cancer [30], and glioma [31] have been proved. We undertook this study to assess the epigenetic effects of ethanol extract of D. sophia seeds (DSE) in an ovalbumin (OVA)-induced mouse model of asthma. A still valid help in medical practice and clinical research, Frontiers in Cellular and Infection Microbiology, SAGE Publications Inc unless otherwise noted. Despite the limitations of this study including its small sample size and the absence of a suitable conventional drug or placebo, we found noticeable effects of Descurainia sophia on adult functional constipation that can be a good reference for future studies. Objectives: To clinically compare D. sophia with PEG 4000 (without electrolyte) in pediatric constipation and to assess its efficacy and side effects. Descurainia sophia in bloom with unripe seedpods, side view. Manuscript content on this site is licensed under Creative Commons Licenses, http://www.creativecommons.org/licenses/by-nc/3.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, complete spontaneous bowel movements per week, http://www.romecriteria.org/assets/pdf/19_RomeIII_apA_885-898.pdf, Remedies for Children Constipation in Medieval Persia. Katalog rostlin s vyhledáváním jednotlivých druhů. Descurainia sophia Photo courtesy Debra L. Cook. Recent data have shown that stool form scales, especially Bristol Stool Form Scale, are responsive to changes in gut transit time and can be used with certainty to monitor motility changes in intestinal function.34 In this research, only 14.3% of patients had a normal type of Bristol Stool Form Scale (type 3 or 4); a high percentage of them, 74.3% of the patients, achieved the normal type of stool form at the end of program. Journal of Evidence-Based Complementary & Alternative Medicine, Epidemiology of constipation in Europe and Oceania: a systematic review, An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking, Epidemiology of constipation in North America: a systematic review, Prevalence of constipation: agreement among several criteria and evaluation of the diagnostic accuracy of qualifying symptoms and self-reported definition in a population-based survey in Spain, Epidemiology of functional constipation and comparison with constipation-predominant irritable bowel syndrome: the Systematic Investigation of Gastrointestinal Diseases in China (SILC), The assessment prevalence of functional constipation and associated factors in adults: a community-based study from Kerman, Southeast, Iran (2011-2012), Rome III Diagnostic Criteria for Functional Gastrointestinal Disorders, Functional Constipation, Complementary and alternative treatments for motility and sensory disorders, Viewpoints of traditional Iranian medicine (TIM) about etiology of pediatric constipation, Abbasian A. viewpoints of Iranian traditional medicine (ITM) about etiology of constipation, Interventions of Iranian traditional medicine for constipation during pregnancy, Phytochemical and pharmacological aspects of, Types of headache and those remedies in traditional Persian medicine, Experimental research on pharmacology and acute toxicology of, Flixweed vs. polyethylene glycol in the treatment of childhood functional constipation: a randomized clinical trial, The functional gastrointestinal disorders and the Rome III process, Psychometric validation of a constipation symptom assessment questionnaire, Diagnostic value of bioelectrical impedance analysis versus body mass index for detection of obesity among students, Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies, A novel sulphur glycoside from the seeds of, Polyethylene glycol versus paraffin for the treatment of childhood functional constipation, Polyethylene glycol 4000 treatment for children with constipation: a randomized comparative multicenter study, Lactulose versus polyethylene glycol for chronic constipation, A placebo-controlled trial of prucalopride for severe chronic constipation, Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation–a 12-week, randomized, double-blind, placebo-controlled study, Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives, A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation, Stool form scale as a useful guide to intestinal transit time, Bristol scale stool form. 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